Ameliorative effect of ethanol extract of Eragrostis tremula Hochst. ex Steud. against diazepam-induced amnesia in mice

Abstract Background Eragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses enhancing potentials and could be beneficial management of amnesia cognitive deficit. Aim This study was aimed at investigating actions E. extract on diazepam-induced mice. Acute toxicity profiling done stated by Organization for Economic Co-operation Development (OECD 425). Oral doses 125, 250 500 mg/kg were studies. Cognitive function evaluated using elevated plus maze (EPM) novel object recognition tests (NORT). The brain tissues concentrations malondialdehyde (MDA), reduced glutathione (GSH) superoxide dismutase (SOD) enzyme-linked immunosorbent assay kits. Results oral median toxic dose assessed to > 5000 substantially ( p < 0.05) transfer latency mice during retention phase EPM test. In NORT, all appreciably exploration time familiar object. Also, it improved index. MDA levels, mg/kg, prevented cortical hippocampal from lesions produced diazepam. Conclusions practically safe after acute administration anti-amnesic actions.